Unlocking Innovative Solutions in Pharmaceutical Development and Contract Research
Comprehensive Pharmaceutical R&D Services
Tailored to Your Needs
Welcome to Avivia, your trusted partner in pharmaceutical development. We specialize in delivering end-to-end solutions to accelerate the drug development process, ensuring efficiency, compliance, and successful outcomes.
Avivia is an independent pharmaceutical development contract organization in the Netherlands (EU) that offers a unique complementary range of pharmaceutical services in the field of:
Why Choose Us?
Expertise: Our team comprises seasoned professionals with a wealth of experience in pharmaceutical development. From concept to pharmaceutical Formulation and beyond, we’ve got you covered.
Custom Solutions: We understand that each project is unique. Our flexible approach allows us to tailor our services to meet your specific requirements, ensuring a personalized experience.
Regulatory Excellence: Navigating the complexIP and regulatory landscape is our forte. Rest easy knowing that your project is in compliance with all industry regulations and standards.
Cutting-edge Technology: Embrace the latest advancements in pharmaceutical science and technology. We leverage state-of-the-art tools and methodologies to drive innovation and efficiency in your projects.
Our pharmaceutical development and technology expertise and capabilities are centered around the development of generics, life cycle management of branded medicines, and complex formulation and chemistry, manufacturing and control (CMC) development of finished dosage forms based on new chemical entities (NCEs).
From life cycle management to new chemical entities
From life cycle management to new chemical entities
Our pharmaceutical development and technology expertise and capabilities are centered around the development of generics, life cycle management of branded medicines, and complex formulation and chemistry, manufacturing and control (CMC) development of finished dosage forms based on new chemical entities (NCEs).
Our Services
From ad-hoc pharmaceutical development services to full CMC development programs
Expeditious support services and full CMC development programs
We support our customers with early-phase pharmaceutical opportunity and strategy evaluation by performing detailed literature searches and reviews, defining freedom to operate and pharmaceutical development strategies for regulatory, patents, formulation development and manufacturing.
In the following pharmaceutical R&D phase we provide pre-clinical formulations and prototype development in combination with full analytical support.
Pharmaceutical Development Services
Analytical R&D Services
Our pharmaceutical analysis experts know what it takes to bring a pharmaceutical product to the market, from discovery, feasibility to cGMP. Having worked with more than 100 unique molecules and even more formulations, we may state that we have faced the most difficult pharmaceutical CMC challenges involved. Avivia offers flexible comprehensive pharmaceutical characterization, stability, forced degradation and compatibility studies, method development and transfer, problem solving and troubleshooting.
Predictive and Biorelevant Dissolution Testing Services
Our dissolution platform takes release testing to the highest level. The experience and knowledge-based dissolution testing services focuses primarily on supporting pharmaceutical formulation development and problem solving. Ideally clinical data is used to tune and validate the dissolution method(s). For us dissolution testing is never a routine test. Our dissolution laboratory is equipped with all relevant dissolution techniques (i.e. USP apparatus I, II, III and IV), and more importantly, we know how and when to apply each system in support of pharmaceutical formulation development, troubleshooting and optimization.
Excipient Characterization and Deformulation Services
Avivia has developed an excipient characterization services to study the chemical composition and purity of excipients and to determine functionality related characteristics (FRCs). With this specific knowledge we have been able to find very specific excipient characteristics that are not part of the routine testing and are not featured on a Certificate of Analysis (CoA) but which do have a profound effect on how the excipient functions within the finished dosage. With this know-how, specific excipient batches, grades or manufacturers can be selected to design pharmaceutical formulations with improved, particular or unique characteristics.
Team work
At Avivia we work in small multidisciplinary pharmaceutical expert teams, allowing the analytical researcher to be directly involved in the process of pharmaceutical formulation development. This rare approach results in an extremely efficient setting.
For example: the knowledgeable researcher can develop effective dissolution methods, and significantly more important information can be derived from each dissolution test. Educated observations made by the researcher during and at the end of the dissolution test provide valuable data about disintegration, hydration, swelling, erosion, particle size, granulation and coating properties, floating, cone formation, sticking, etc. Discussing these observations during interactions with the pharmaceutical developer offers additional guidance in the evaluation of dissolution profiles, release mechanisms, excipient performance and setting process parameters.
Transfer to cGMP
In the final phase Avivia takes care of the investigational medicinal product dossier (IMPD), analytical method transfer, CMO selection and scale-up. Avivia has access to flexible small-scale pharmaceutical GMP production area with state-of-the-art equipment.
Contact us
Ready to take the next step in your pharmaceutical development journey? Contact us today to discuss your project requirements and explore how we can help you achieve success.
